期刊论文

中文

中国中医药信息杂志

1005-5304

2010

17

6

31-33

10.3969/j.issn.1005-5304.2010.06.014

湖南省教育厅重点项目（05A031）；

本校为第一机构

目的 观察妇科止血消痛颗粒对产后子宫复旧不全大鼠子宫组织基质金属蛋白-9(MMP-9)、组织金属蛋白酶抑制物-1 (TIMP-1)表达的影响,探讨妇科止血消痛颗粒治疗产后子宫复旧不全的机制.方法 建立大鼠产后子宫复旧不全病理模型,随机分为模型组、产妇康组及妇科止血消痛颗粒高、中、低剂量组.造模第1日开始各给药组分别灌胃相应药物,空白组、模型组予蒸馏水灌胃.均每日1次,连续7 d.采用原位杂交法检测各组大鼠子宫组织中MMP-9、TIMP-1基因的表达水平.结果 各组大鼠子宫内膜中均可检测到MMP-9和TIMP-1的杂交信号.模型组MMP-9表达强度明显超过空白组,TIMP-1表达弱于空白组.妇科止血消痛颗粒高、中、低剂...

Objective To explore the mechanism of Fuke Zhixuexiaotong Keli in rats model of incomplete puerperal involution of uterus by detecting the expression of metalloproteinases-9 （MMP-9） and tissue inhibitor of metalloproteinase-1 （TIMP-1） in the uterine redintegration incomplete model. Methods Seventy- two SD female rats were randomly divided into 6 groups： blank group, model group, Chanfukang group, and high-, middle-, low-dose of Fuke Zhixuexiaotong Keli group. The model of incomplete puerperal involution of uterus was established, and MMP-9...