期刊论文

中文

中国中医药信息杂志

1005-5304

2015

22

8

63-66

10.3969/j.issn.1005-5304.2015.08.017

国家自然科学基金（81373816） 湖南省研究生科研创新项目（CX2013B327）

本校为第一机构

目的探讨益心泰颗粒对慢性心力衰竭(chronic heart failure,CHF)兔心肌组织原癌基因C-Myc蛋白及mRNA表达的影响。方法采用阿霉素耳缘静脉注射建立CHF兔模型,将成模家兔随机分为模型组、氯沙坦钾组和益心泰低、中、高剂量组,另设正常组。各给药组给予相应药物灌胃,模型组和正常组给予等体积生理盐水灌胃,每日1次,连续4周。观察心功能指标,检测心肌组织C-Myc蛋白及mRNA表达。结果与正常组比较,模型组左心室射血分数(LVEF)、左心室短轴缩短率(LVFS)、E峰与A峰的比值(E/A)显著降低(P

Objective To explore the effects of Yixintai Granules on expression of C-Myc mRNA andits protein in myocardial tissues of rabbits with chronic heart failure （CHF）. Methods CHF rabbitmodels were established by ear marginal vein injection of adriamycin. Successfully modeledrabbits were divided into the model group, the Losartan Potassium group, the high-, medium-, andlow dose Yixintai Granules groups. Besides, a normal control group was set up. Administrationgroups were given relevant medicine for gavage, equal volume of physiological saline wa...