期刊论文

中文

中国中医药信息杂志

1005-5304

2015

22

4

67-69

10.3969/j.issn.1005-5304.2015.019

湖南省科学技术厅科技计划(2013SK3085)； 湖南省中医药科研计划项目(2013118)； 湖南中医药大学重点学科建设项目-病理学与病理生理学(2012年)；

本校为第一机构

目的探讨六味地黄汤抗肾间质纤维化的作用机制。方法采用5/6肾切除法复制肾间质纤维化大鼠模型,随机分为假手术组、模型组、六味地黄汤组和依那普利组。六味地黄汤组予6.25 g/(kg?d)六味地黄汤灌胃,依那普利组予10 mg/(kg?d)马来酸依那普利悬浊液灌胃,假手术组和模型组予10 mL/(kg?d)蒸馏水灌胃,每日1次,连续12周。采用免疫组化法检测缺氧诱导因子-1α(HIF-1α)和Ⅰ、Ⅲ型胶原(CollⅠ、CollⅢ)在肾组织中的表达。结果与假手术组比较,模型组肾组织中HIF-1α、CollⅠ、CollⅢ的表达均明显升高(P

Objective To discuss the mechanism of Liuwei Dihuang Decoction against renal interstitial fibrosis. Methods The rat models of renal interstitial fibrosis were induced by 5/6 nephrectomy, and were randomly divided into sham-operation group, model group, Liuwei Dihuang Decoction group and enalapril group. Liuwei Dihuang Decoction group was given 6.25 g/(kg?d) of Liuwei Dihuang Decoction for gavage, enalapril group was given 10 mg/(kg?d) enalapril for gavage, sham-operation group and model group were given 10 mL/(kg?d) of distilled water for gavag...