期刊论文

Effects of Xiaoyao Kang'ai Jieyu Formula on Depressive Symptoms of Mice with Breast Cancer Related Depression

中文

中国中医药信息杂志

1005-5304

2018

25

11

46-51

10.3969/j.issn.1005-5304.2018.11.011

湖南省自然科学基金青年基金(2017JJ3235) 湖南省教育厅优秀青年资助项目(17B201) 湖南省教育厅创新平台开放基金项目(16K067)。

本校为第一机构

目的 观察逍遥抗癌解郁方对乳腺癌并发抑郁症模型小鼠的影响,探讨其作用机制.方法 以BALB/c雌性小鼠为研究对象,采用腋下注射4T1炎性乳腺癌细胞联合腹腔注射皮质酮(CORT)建立乳腺癌并发抑郁症模型小鼠.根据糖水消耗量随机分为空白组、模型组、紫杉醇组、逍遥抗癌解郁方组、化疗+氟西汀组、化疗+逍遥抗癌解郁方组,分别给予相应药物21 d后,采用糖水偏好实验、Open-field实验和新奇摄食实验检测小鼠行为学变化;ELISA检测小鼠血浆促肾上腺激素释放激素(CRH)、促肾上腺皮质激素(ACTH)、CORT,血清 5-羟色胺(5-HT)、多巴胺(DA)、去甲肾上腺素(NE),肿瘤标志物糖类抗原 CA153、CA125和癌胚抗原(CEA)的含量...

Objective To investigate the effects of Xiaoyao Kang'ai Jieyu Formula on mice with breast cancer related depression; To explore its mechanism. Methods BALB/c female mice were set as study objects. Subaxillary injection of inflammatory 4T1 cells and intraperitoneal injection of corticosterone were used to establish a model of breast cancer related depression. According to the consumption of sugar water, mice were randomly divided into blank group, model group, paclitaxel group, Xiaoyao Kang'ai Jieyu Formula group, chemotherapy + fluoxetine group, and chemotherapy + Xiaoyao Kang'ai Jieyu Formula...