期刊论文

中文

中国中医药信息杂志

1005-5304

2018

25

5

36-40

10.3969/j.issn.1005-5304.2018.05.009

2014CB543102:国家重点基础研究发展计划（973计划） 81673886:国家自然科学基金

本校为第一机构

目的观察不同电针刺激强度对糖尿病胃轻瘫(DGP)大鼠胃肠运动和饥饿素的影响,探讨不同电针刺激强度治疗DGP的效应差异。方法60只SD大鼠随机分为空白组、模型组和小、中、大刺激量组,每组12只。采用单次腹腔注射2%链脲佐菌素配合高脂高糖饮食建立DGP大鼠模型。造模成功后,分别采用电针小、中、大刺激量进行干预,连续15 d。用血糖仪和血糖试纸每周测定血糖;治疗结束后以酚红为标记物,观察大鼠胃排空率及小肠推进率;ELISA检测血清饥饿素含量,RT-PCR检测下丘脑饥饿素的mRNA表达,免疫组化检测下丘脑饥饿素的蛋白表达。结果与空白组比较,模型组大鼠胃排空率及小肠推进率显著降低,血清饥饿素含量、下丘脑...

Objective To observe the effects of different electroacupuncture (EA) intensity on gastrointestinal motility and expression of Ghrelin in hypothalamus in diabetic gastroparesis (DGP) rats; To explore the effedt differences of different EA intensity. Methods Sixty rats were randomly divided into normal control group, model group, weak EA stimulation group, middle EA stimulation group, and strong EA stimulation group, with 12 rats in each group. The DGP model was established by intraperitoneal injection of 2% streptozotocin and raised by high-sugar and high-fat fodder. After modeling, each EA st...