期刊论文

Effects of Ganwei Baihe Decoction on Protein Expressions of TFF1 and p-ERK in Gastric Mucosa of Model Mice with Chronic Stress and Helicobacter Pylori Double Injury Factors

中文

中国中医药信息杂志

1005-5304

2018

25

10

44-48

10.3969/j.issn.1005-5304.2018.10.011

湖南省中医药管理局重点课题（201512） 湖南省教育厅科学研究重点项目（17A158）

本校为第一机构

目的 观察肝胃百合汤对慢性应激与幽门螺杆菌(Hp)双重损伤因素模型小鼠胃黏膜组织三叶因子1 (TFF1)、磷酸化细胞外信号调节激酶(p-ERK)蛋白表达的影响,探讨其治疗慢性应激性胃溃疡合并Hp感染的相关机制.方法 将60只BALB/c雄性小鼠随机分为空白组、应激组、单纯Hp组、双重因素组、肝胃百合汤组、雷尼替丁组,每组10只,选取10种不可预知刺激因素制备慢性应激小鼠模型,造模第7日给予单纯Hp组、双重因素组、肝胃百合汤组、雷尼替丁组灌胃Hp菌液;肝胃百合汤组给予肝胃百合汤灌胃,雷尼替丁组给予雷尼替丁灌胃,其余各组给予蒸馏水灌胃.采用免疫组化检测小鼠胃黏膜组织TFF1、p-ERK蛋白表达.结果 双重因素...

Objective To observe the effects of Ganwei Baihe Decoction on the protein expressions of TFF1 and p-ERK in gastric mucosa of model mice with chronic stress and Helicobacter pylori (Hp) double injury factors; To explore the relevant mechanism for treating chronic stress gastric ulcer complicated with Hp infection. Methods Totally sixty BALB/c male mice were randomly divided into blank group, stress group, Hp group, double factors group, Ganwei Baihe Decoction group, and ranitidine group, with 10 mice in each group. 10 unpredictable stimulus factors were selected to prepare chronic stress mouse ...