期刊论文

Effects of Yiqi Huoxue Xiaozheng Formula on Apoptosis of Rats with Benign Prostatic Hyperplasia

中文

中国中医药信息杂志

1005-5304

2018

25

9

52-55

10.3969/j.issn.1005-5304.2018.09.013

国家自然科学基金面上项目（81673984） 湖南省技术创新引导计划临床医疗技术创新引导项目（2017SK50305） 湖南省中医药科研计划项目（201832） 全国名老中医药专家传承工作室建设项目（2014年）

本校为第一机构

目的观察益气活血消癥方对良性前列腺增生大鼠细胞凋亡的影响,初步探讨其作用机制。方法将60只8周龄雄性SD大鼠随机分为正常组、阳性对照组和消癥方低、中、高剂量组,每组10只。除正常组外,其余各组大鼠均予去势加丙酸睾酮注射法复制前列腺增生模型。正常组和模型组大鼠予生理盐水灌胃,消癥方低、中、高剂量组大鼠分别予益气活血消癥方10、20、40 mg/100 g灌胃,阳性对照组大鼠予癃开颗粒混悬液11 mg/100 g灌胃,1次/d,连续30 d。末次给药24 h后,脱颈处死大鼠,取前列腺组织,免疫组化检测大鼠前列腺组织Bcl-2、Bax蛋白表达。结果与正常组比较,模型组大鼠前列腺组织Bax表达显著降低,Bcl-2表达显著升...

Objective To investigate the effects of Yiqi Huoxue Xiaozheng Formula on cell apoptosis in rats with benign prostatic hyperplasia (BPH); To preliminarily explore its mechanism of action. Methods Totally sixty 8-week-old male SD rats were randomly devided into normal group, positive control group, Yiqi Huoxue XiaozhengFormula low-, medium-, and high-dose groups, with 10 rats in each group. Except for the rats in normal group, rats in other groups were treated with castrate and testosterone propionate injection to replicate BPH model. The normal group and the model group were given normal saline...