期刊论文

Study on Mechanism of Compatibility of Main Active Components of Astragali Radix and Notoginseng Radix et Rhizoma on Cerebral Ischemic Injury Based on Network Pharmacology

中文

中国中医药信息杂志

1005-5304

2019

26

7

109-113

10.3969/j.issn.1005-5304.2019.07.024

国家自然科学基金(81503385).

本校为第一机构

目的采用网络药理学方法探讨黄芪和三七主要有效成分配伍抗缺血性脑损伤作用机制,为成分筛选提供参考。方法文献检索结合前期研究确定黄芪和三七抗缺血性脑损伤主要有效成分,通过DRAR-CPI数据库预测有效成分作用靶点,多数据库联合检索脑缺血相关疾病靶点。采用Cytoscape3.2.1软件构建有效成分-靶点网络、作用靶点蛋白相互作用(PPI)网络及疾病靶点PPI网络,交叉融合并筛选核心靶点。利用DAVID数据库对核心靶点进行生物过程和信号通路富集分析。结果筛选出的194个核心靶点主要关联脑缺血凋亡、自噬、神经营养因子的保护作用、血管新生及炎症反应等多个过程。此外,靶点参与了脑缺血中PI3K-Akt信号通...

Objective To discuss the mechanism of compatibility of main active components of Astragali Radix and Notoginseng Radix et Rhizoma on cerebral ischemic injury through network pharmacology.Methods Main active components of Astragali Radix and Notoginseng Radix et Rhizoma for the treatment of cerebral ischemic injury were determined through literature search combined with preliminary experimental research.Through the DRAR-CPI database,main active components were predicted and collected,and the targets were associated with cerebral ischemia.In addition,targets for cerebral ischemia-related disease...