This article summarized the academic thoughts and clinical experience of national TCM master Liu Zuyi in the treatment of miscellaneous diseases. Master Liu believes that five internal organs are in harmony of each other and the Middle-jiao of spleen and stomach is the root of the health, and miscellaneous diseases are mostly born from the spleen and stomach. Therefore, the spleen and stomach can be regulated to treat disorder of five internal organs, and the thought of regulating Middle-jiao for miscellaneous ...