期刊论文

Study on Serum Metabolomics of Knee Osteoarthritis with Liver-kidney Deficiency Syndrome Intervened by Jiawei Duhuo Jisheng Mixture

中文

中国中医药信息杂志

1005-5304

2020

27

11

23-28

10.19879/j.cnki.1005-5304.202004087

国家自然科学基金(81874476) 国家重点研发计划(2018YFC2002500) 第六批全国名老中医药专家学术经验继承项目(rsk-011-14) 湖南省自然科学基金(2018JJ2303、2019JJ50462) 湖南省科技厅创新项目(2017SK50302) 湖南省中医药科研计划(2015165) 湖南省卫生健康委科研计划(20200442) 湖南中医药大学校级课题(ZYYDX201726、2018XJJJ39) 湖南中医药大学中医学一流学科建设项目(2018ZYX61、2018ZYX63)。

本校为第一机构

目的采用气相色谱-质谱联用技术(GC-MS)的代谢组学方法,探讨加味独活寄生合剂对膝骨关节炎(KOA)肝肾亏虚证的疗效机制。方法选择25名KOA肝肾亏虚证患者,予加味独活寄生合剂,62.5 mL/次,2次/d,口服,7 d为1个疗程,共4个疗程。采用GC-MS检测患者治疗前后血清,并进行多元统计分析。结果患者治疗后血清中乳酸、丙氨酸、甘油、琥珀酸、葡萄糖、花生四烯酸含量明显降低,氨基丙二酸、苏氨酸、脯氨酸、肌醇含量明显上升(P

Objective To explore the mechanism of Jiawei Duhuo Jisheng Mixture on knee osteoarthritis(KOA) with liver-kidney deficiency syndrome by GC-MS metabolomics methods.Methods Totally 25 patients of KOA with liver-kidney deficiency syndrome were randomly selected and treated with Jiawei Duhuo Jisheng Mixture,62.5 mL/time,twice a day,7 days a course,4 courses for oral administration.The serum of the patients before and after treatment was detected by GC-MS and the metabolic data were analyzed by multivariate statistical analysis.Results After the treatment of Jiawei Duhuo Jisheng Mixture,the content...