期刊论文

Study on Molecular Network Regulation Mechanism of Zuojin Pills Against Helicobacter Pylori Infection

中文

中国中医药信息杂志

1005-5304

2020

27

5

90-96

10.3969/j.issn.1005-5304.201905115

81703920:国家自然科学基金 2019M662790:中国博士后科学基金 2019JJ50442:湖南省自然科学基金 201780:国家自然科学基金 2017280:湖南省大学生研究性学习和创新性实验计划 201908:湖南省大学生研究性学习和创新性实验计划 2018XJJJ28:湖南中医药大学校级科研基金项目 201610:青年教师科研项目 2018ZYX20:湖南中医药大学中医学一流学科开放基金

本校为第一机构

目的 基于网络药理学和生物信息学方法探究左金丸抗幽门螺杆菌(Hp)感染的分子网络调控机制.方法 通过中药系统药理学数据库和分析平台(TCMSP)检索左金丸化学成分,筛选并预测其入血活性成分和作用靶点,检索疾病数据库中与Hp感染相关的作用靶点,构建左金丸成分靶点与疾病靶点的交互网络,获得左金丸抗Hp的特征性基因;通过DAVID6.8数据库对上述特征性基因进行GO功能富集和KEGG通路富集分析;利用Cytohubba筛选出左金丸抗Hp感染的关键靶点.结果 通过TCMSP筛选、预测得到左金丸32个入血活性成分和197个作用靶点.GO分析共得到199条富集结果,其中生物过程包含炎症反应、RNA信号转录、信号传导等152条,细胞...

Objective To study the molecular network regulation mechanism of Zuojin Pills against Helicobacter pylori (Hp) infection based on network pharmacology and bioinformatics. Methods By searching all the components of Zuojin Pills in TCMSP, the possible active components and targets were screened and predicted. The targets related to Hp infection were selected in 5 major disease databases, and then the interaction network between component targets and disease targets was constructed to obtain the characteristic gene of Zuojin Pills against Hp infection. GO functional enrichment and KEGG pathway en...