期刊论文

Discussion on Molecular Mechanism of Danshen Decoction on Diabetic Cardiomyopathy Based on Network Pharmacology

中文

中国中医药信息杂志

1005-5304

2020

27

3

78-83

10.3969/j.issn.1005-5304.201812376

国家自然科学基金面上项目（81573956）；

本校为第一机构

目的采用网络药理学方法探讨丹参饮治疗糖尿病心肌病的化学成分、作用靶点及可能作用机制。方法应用TCM database@Taiwan、Chemistry Database、HIT及Batman-TCM数据库获取丹参饮的化学活性成分及相关靶点信息,通过对比CTD及Gencards数据库,归纳丹参饮化学成分中明确对糖尿病心肌病具有治疗作用的靶基因,构建成分-靶点网络图。综合药物-疾病靶基因,使用String10.5构建靶点相互作用网络,使用Cytoscape3.6.1软件的Network Analyzer工具进行拓扑分析,对丹参饮关键化学成分及靶基因进行评价。通过DAVID6.8数据库对靶点基因功能进行富集分析,通过KEGG通路分析获得参与的相关作用通路。结果筛选得到丹...

Objective To explore the chemical components, targets, and potential mechanism of Danshen Decoction in treating of diabetic cardiomyopathy based on network pharmacology.Methods The TCM database@Taiwan, Chemistry Database, HIT and Batman-TCM database were used to obtain information about chemical active components and targets of Danshen Decoction.By comparing the CTD and Gencards databases, the target genes that had a therapeutic effect on diabetic cardiomyopathy in the chemical components of Danshen Decoction were concluded.A component-target network map was constructed, and the core target in...