期刊论文

Clinical Study on Qilian Jiechangning Decoction for Treatment of Diarrhea-predominant Irritable Bowel Syndrome with Spleen Deficiency and Damp Heat Syndrome

中文

中国中医药信息杂志

1005-5304

2021

28

02

92-96

10.19879/j.cnki.1005-5304.202008007

全国名老中医药专家传承工作室建设项目（2013年）； 湖南中医药大学国内一流学科建设资助项目（2018-2020年）；

本校为第一机构

目的 观察芪连结肠宁方治疗腹泻型肠易激综合征(IBS-D)脾虚湿热证的临床疗效、安全性,以及对脑肠肽、肠黏膜屏障功能的影响.方法 采用随机数字表法将96例患者分为观察组和对照组各48例,治疗期间观察组脱落3例,对照组脱落2例、失访1例.观察组予芪连结肠宁方,每日1剂,每日2次,口服.对照组予马来酸曲美布汀胶囊,0.2 g/次,3次/d,口服;双歧杆菌四联活菌片,0.5 g/次,3次/d,口服.2组均连续治疗4周.观察2组临床疗效,比较2组治疗前后中医症状评分、肠易激综合征症状严重程度量表(IBS-SSS)积分、肠易激综合征生活质量量表(IBS-QOL)评分及血清5-羟色胺(5-HT)、血管活性肠肽(VIP)、P物质、二胺氧化酶(DAO)、...

Objective To observe the clinical efficacy and safety of Qilian Jiechangning Decoction for the treatment of diarrhea-predominant irritable bowel syndrome (IBS-D)with spleen deficiency and damp heat syndrome and its effects on brain-gut peptide and intestinal mucosal barrier function.Methods Totally 96 patients were divided into the observation group and the control group (48 cases in each group)by random number table method.45 patients in observation group completed the therapy (3 patients were falling off), and 45 patients in control group completed the therapy (2 patients were falling off an...