期刊论文

Network Pharmacology Research and Experimental Calidation of Polygonimultiflori Radix- Acori Tatarinowii Rhizoma in Treating Alzheimer Disease

中文

中国中医药信息杂志

1005-5304

2021

28

08

36-41

10.19879/j.cnki.1005-5304.202005395

国家自然科学基金（81373702、81874462）；

本校为第一机构

目的应用网络药理学方法预测何首乌-石菖蒲药对治疗阿尔茨海默病的作用靶点及相关信号通路,探讨其作用机制。方法通过中药系统药理学数据库与分析平台（TCMSP）检索并筛选何首乌、石菖蒲的潜在活性成分,并查询活性成分作用靶点,采用DrugBank数据库和Pharmmapper服务器预测有效化学成分的作用靶点,采用Cytoscape3.7.1软件构建活性成分-靶点网络;通过DrugBank、DisGeNET、HPO数据库检索阿尔茨海默病相关基因;将活性成分作用靶点和阿尔茨海默病相关基因进行比对,得到交集靶点,利用STRING数据库构建蛋白相互作用网络;使用Cytoscape3.7.1软件根据度值、介数和紧密度筛选关键靶点,应用Metascape数据库...

Objective To predict the targets and related signaling pathways of Polygonimultiflori Radix-Acori Tatarinowii Rhizoma in the treatment of Alzheimer disease and explore the mechanism by network pharmacology method. Methods The potential active components of Polygonimultiflori Radix and Acori Tatarinowii Rhizoma were searched and screened through TCMSP databases, and queried the target points of the active ingredients. The targets of the effective chemical constituents of Polygonimultiflori Radix-Acori Tatarinowii Rhizoma was predicted by DrugBan...