期刊论文

中文

中国中医药信息杂志

1005-5304

2024

31

2

130-137

10.19879/j.cnki.1005-5304.202303286

82102278:国家自然科学基金 2020JJ8010:湖南省自然科学基金项目 2021JJ40292:湖南省自然科学基金项目 2019RS1067:湖南创新型省份建设专项

本校为第一机构

目的采用代谢组学与网络药理学方法探讨羟基红花黄色素A(HSYA)治疗脓毒症急性肝损伤作用机制。方法将50只C57BL/6小鼠随机分为假手术组(10只)、脓毒症组(20只)和HSYA组(20只),采用盲肠结扎穿刺法构建脓毒...展开更多 目的采用代谢组学与网络药理学方法探讨羟基红花黄色素A(HSYA)治疗脓毒症急性肝损伤作用机制。方法将50只C57BL/6小鼠随机分为假手术组(10只)、脓毒症组(20只)和HSYA组(20只),采用盲肠结扎穿刺法构建脓毒症急性肝损伤小鼠模型,HSYA组造模后2 h皮下注射HSYA(2.25 mg/kg)。检测小鼠血清炎症因子含量及肝功能,HE染色观察肝组织病理变化,超高效液相色谱-四级杆-飞行时间质谱(UPLC-Q-TO...

Objective To explore the mechanism of hydroxyl safflower flavin A(HSYA)in the treatment of sepsis-induced liver injury by using metabolomics and network pharmacology.Methods A total of 50 male C57BL/6 mice were randomly divided into sham-operation group(10 mice),sepsis ...MORE Objective To explore the mechanism of hydroxyl safflower flavin A(HSYA)in the treatment of sepsis-induced liver injury by using metabolomics and network pharmacology.Methods A total of 50 male C57BL/6 mice were randomly divided into sham-operation group(10 mice),sepsis gr...