Extrachromosomal Circular DNA (eccDNA): From Chaos to Function

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Zuo, Shanru;Yi, Yihu;Wang, Chen;Li, Xueguang;Zhou, Mingqing;...

通讯作者：

He, Quanyuan

作者机构：

[Zuo, Shanru] Cent South Univ, Xiangya Hosp 3, Dept Pharm, Changsha, Peoples R China.

[Zuo, Shanru; Li, Xueguang; Zhou, Junhua; He, Quanyuan; Yang, Yide] Hunan Normal Univ, Sch Med, Key Lab Model Anim & Stem Cell Biol Hunan Prov, Changsha, Peoples R China.

[Yi, Yihu] Wuhan Union Hosp, Dept Orthopaed, Wuhan, Peoples R China.

[Wang, Chen] Cent South Univ, Xiangya Hosp 3, Dept Obstet & Gynecol, Changsha, Peoples R China.

[Zhou, Mingqing] Sun Yat Sen Univ, Zhongshan Peoples Hosp, Zhongshan Hosp, Zhongshan, Peoples R China.

通讯机构：

[He, Quanyuan] H

Hunan Normal Univ, Sch Med, Key Lab Model Anim & Stem Cell Biol Hunan Prov, Changsha, Peoples R China.

语种：

英文

关键词：

eccDNA;Circulome;Biogenesis;Cancer;biomarker

期刊：

Frontiers in Cell and Developmental Biology

ISSN：

2296-634X

年：

2022

卷：

页码：

792555

DOI：

10.3389/fcell.2021.792555

基金类别：

This work was supported by the National Natural Science Foundation of China (31771445), the Major Scientific and Technological Project for Collaborative Prevention and Control of Birth Defect in Hunan Province (2019SK1012), and the High-Level Talent Program in Hunan Province (2019RS1035).

机构署名：

本校为其他机构

院系归属：

中医学院

摘要：

Extrachromosomal circular DNA (eccDNA) is a type of double-stranded circular DNA that is derived and free from chromosomes. It has a strong heterogeneity in sequence, length, and origin and has been identified in both normal and cancer cells. Although many studies suggested its potential roles in various physiological and pathological procedures including aging, telomere and rDNA maintenance, drug resistance, and tumorigenesis, the functional relevance of eccDNA remains to be elucidated. Recently, due to technological advancements, accumulated evidence highlighted that eccDNA plays an importan...

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Extrachromosomal Circular DNA (eccDNA): From Chaos to Function

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