Kai Xin San aqueous extract improves Aβ1-40-induced cognitive deficits on adaptive behavior learning by enhancing memory-related molecules expression in the hippocampus

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Lu, Cong;Shi, Zhe;Sun, Xiuping;Pan, Ruile;Chen, Shanguang;...

通讯作者：

Liu, Xinmin

作者机构：

[Pan, Ruile; Lu, Cong; Sun, Xiuping; Shi, Zhe; Liu, Xinmin] Chinese Acad Med Sci, Inst Med Plant Dev IMPLAD, Res Ctr Pharmacol & Toxicol, Beijing, Peoples R China.

[Pan, Ruile; Lu, Cong; Sun, Xiuping; Shi, Zhe; Liu, Xinmin] Peking Union Med Coll, Beijing, Peoples R China.

[Chen, Shanguang; Li, Yinghui; Qu, Lina] China Astronaut Res & Training Ctr, Beijing, Peoples R China.

[Sun, Lihua; Dang, Haixia] Chinese Acad Chinese Med Sci, Beijing, Peoples R China.

[Chen, Lingling; Bu, Lanlan; Liu, Xinmin] Hunan Univ Tradit Chinese Med, Changsha, Hunan, Peoples R China.

通讯机构：

[Liu, Xinmin] C

[Liu, Xinmin] P

[Liu, Xinmin] H

Chinese Acad Med Sci, Inst Med Plant Dev IMPLAD, Res Ctr Pharmacol & Toxicol, Beijing, Peoples R China.

Peking Union Med Coll, Beijing, Peoples R China.

语种：

英文

关键词：

Abeta(1-40);Cognitive deficits;Kai Xin San;Memory-related molecules;Reward-directed instrumental learning

期刊：

Journal of Ethnopharmacology

ISSN：

0378-8741

年：

2017

卷：

201

页码：

73-81

DOI：

10.1016/j.jep.2016.10.002

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [30973888]; Ministry of Science and Technology of ChinaMinistry of Science and Technology, China [2011DFA32730, 2012-ZX09J12201]; Foundation of State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center [SMFA10B01, SMFA12B05]

机构署名：

本校为通讯机构

摘要：

Ethnopharmacological relevance Kai Xin San (KXS), a traditional formula of Chinese medicine, has been used to treat dementia. Aim of the study The present study aimed to investigate its ameliorating effects on Aβ 1-40 -induced cognitive impairment in rats using a series of novel reward-directed instrumental learning tasks, and to determine its possible mechanism of action. Materials and methods Rats were pretreated with KXS aqueous extract (0.72 and 1.44 g/kg, p.o.) for 10 days, and were trained to gain reward reinforcement by lever pressing a...

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Kai Xin San aqueous extract improves Aβ1-40-induced cognitive deficits on adaptive behavior learning by enhancing memory-related molecules expression in the hippocampus

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