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Genetic association between human skin microbiota with vaginitis: a two-sample Mendelian randomization study

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成果类型:
期刊论文
作者:
Zhang, Yuxue;Chen, Huihui;Shi, Yiming;Jiang, Lingling*;Hong, Shihao
通讯作者:
Jiang, Lingling;Hong, SH
作者机构:
[Jiang, Lingling; Zhang, Yuxue; Hong, Shihao; Jiang, LL] Zhejiang Univ, Zhejiang Key Lab Precise Protect & Promot Fertil, Zhejiang Prov Clin Res Ctr Obstet & Gynecol,Sch Me, Assisted Reprod Unit,Dept Obstet & Gynecol,Sir Run, Hangzhou 310016, Peoples R China.
[Chen, Huihui] Ninghai Maternal & Child Hlth Hosp, Dept Obstet & Gynecol, Ningbo, Peoples R China.
[Shi, Yiming] Hunan Univ Chinese Med, Changsha 410208, Hunan, Peoples R China.
通讯机构:
[Hong, SH ; Jiang, LL] Z
Zhejiang Univ, Zhejiang Key Lab Precise Protect & Promot Fertil, Zhejiang Prov Clin Res Ctr Obstet & Gynecol,Sch Me, Assisted Reprod Unit,Dept Obstet & Gynecol,Sir Run, Hangzhou 310016, Peoples R China.
语种:
英文
关键词:
Amplicon sequence variation (ASV);Human skin microbiota;Mendelian randomization (MR);Meta-analysis;Vaginitis
期刊:
ARCHIVES OF DERMATOLOGICAL RESEARCH
ISSN:
0340-3696
年:
2025
卷:
317
期:
1
页码:
191
基金类别:
Zhejiang Province "Leading Talents" research and development project [2023C03033]
机构署名:
本校为其他机构
摘要:
The human skin microbiome is closely associated with various diseases. We aimed to find the causal association of the human skin microbiome with vaginitis. A two-way two-sample Mendelian randomization study used summary statistics of the human skin microbiota from the largest genome-wide association study meta-analysis. Pooled statistics for vaginitis disease were obtained from the FinnGen consortium R10 release. Inverse variance weighted, MR-Egger, weighted median, weighted model, MR-PRESSO, and STEIGER methods were used to test for causal associations between different parts of the human ski...

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