期刊论文

中文

中华中医药杂志

1673-1727

2010

25

9

1483-1485

湖南省科技厅重点项目（No.06SK2005）~~；

本校为第一机构

目的:研究超微粉碎对肿痛消巴布剂中异鼠李素-3-0-新橙皮苷透皮吸收的影响.方法:利用改良 Fran.透皮吸收池进行体外透皮试验,HPLC法测定超微肿痛消与普通肿痛消中异鼠李素-3-O-新橙皮苷含量.结果:超微肿痛消巴布膏剂的Q-t方程为Q=3.0382t+47.082、透皮速率为3.0382(μg.cm~2/h),普通肿痛消巴布膏剂的Q-t方程为Q=2.7967t+39.752、透皮速率为2.7967(μg·cm~2/h).结论:超微肿痛消巴布剂中异鼠李素-3-O-新橙皮苷累计渗透量与透皮速率均优于其普通肿痛消巴布剂,说明超微粉碎技术加快了药物成分的溶出

Objective：To study the effect of ultramicro-shatter technology on penetrating skin absorption of isorhamnetin-3-O-neohesperidin in Zhongtongxiao Cataplasm.Methods：To apply reformed Frans penetrating skin absorption cell marching extraorgan penetrating skin experiment.HPLC method was used to determine the content of isorhamnetin-3-Oneohesperidin in ultramicro-shatter Zhongtongxiao Cataplasm and in common Zhongtongxiao Cataplasm.Results：The Q-t equation of ultramicro-shatter Zhongtongxiao Cataplasm：Q=3.0382t＋47.082,penetrating skin velocity：...