期刊论文

中文

中华中医药杂志

1673-1727

2012

27

9

2321-2325

30772696:国家自然科学基金 30973717:国家自然科学基金

本校为第一机构

目的:观察养心通脉有效部位方(apr-YTF)对大鼠骨髓间充质干细胞(BMSCs)归巢梗死心肌的影响。方法:将急性心肌梗死大鼠模型随机分成apr-YTF注射液、rhG-CSF注射液和PBS缓冲液3组,测量各组大鼠干预后在体心功能、心室肌瘢痕面积、瘢痕毛细血管数、心肌CD_34+细胞、Brdu与cTn I双染阳性细胞数、Ⅷ因子、VEGF、bFGF、Flk-1、外周血CD_34+细胞数,分析组间差异。结果:①与PBS组比较,apr-YTF组和rhG-CSF组的LVSP、LVEDP、+dp/dtmax、-dp/dtmax均有显著改善,心室肌瘢痕面积显著减小,心室肌毛细血管数、心肌边缘区和外周血液CD_34+染色阳性细胞数、心肌梗死边缘区中Brdu与cTn I双染阳性细胞数及Ⅷ因子、F...

Objective： To observe the effect of Yangxin Tongmai Formula effective components recipe on bone marrow mesenchymal stem cells homing to the infarcted myocardium in rats. Methods： The acute myocardial infarction （AMI） rat model was devided into apr-YTF injection group, rhG-CSF injection group, PBS buffer solution group, then the rat heart function in vivo was examined; the ventricular scar area and capillary counts were detected; the CD34＋ and myocardial Brdu and cTnI double dyeing positive cells counts, and the content of factor VHI, VEGF,...