期刊论文

中文

中华中医药杂志

1673-1727

2015

30

8

2911-2913

(No.30901921):国家自然科学青年基金资助项目 (No.30901921):Young Scientists Fund of the National Natural Science Foundation of China

本校为第一机构

目的:探讨咳喘宁含药血清对呼吸道合胞病毒诱发大鼠哮喘模型CD_4 ~+ T、CD_8 ~+T细胞内PI3K、STAT6的干预作用。方法:制作呼吸道合胞病毒诱发大鼠哮喘模型,提取并培养CD_4 ~+ T、CD_8 ~+T细胞,采用RT-PCR和Western Blot方法观察咳喘宁含药血清对呼吸道合胞病毒诱发大鼠哮喘模型CD_4 ~+ T、CD_8 ~+T细胞内PI3K、STAT6的干预作用。结果:咳喘宁组PI3K mRNA、STAT6 mRNA表达量均较模型组和阳性药组降低,差异有统计学意义(P

Objective： To investigate the intervention effect of serum containing methoxyphenamini hydrochloridum on expression of PI3K and STAT6 in CD：T and CD＋T cells of asthma rat model induced by respiratory syncytial virus. Methods： Asthma rat model was established by using respiratory syncytiai virus. The intervention effect of serum containing methoxyphenamini hydrochloridum on expression of PI3K and STAT6 in CD：T and CD＋T cells of asthma rat model induced by respiratory syncytial virus were observed by using RT-PCR and Western-blotting method...