期刊论文

Effects of Zhibai Dihuang Decoction on activity of Na~+-K~+-ATP enzyme and Ca~(2+)-Mg~(2+)- ATP enzyme in sperm of ureaplasma urealyticum infected rat model

中文

中华中医药杂志

1673-1727

2017

32

4

1528-1531

国家自然科学基金项目(No.81603634,No.81373641) 湖南省中医药管理局课题资助项目(No.2015101)~~

本校为第一机构

目的:研究知柏地黄汤对解脲脲原体（UU）感染模型大鼠精子线粒体Na+-K+-ATP酶、Ca2+-Mg2+-ATP酶的影响。方法:80只雄性SD大鼠,随机分成假手术组、模型组、中药组（知柏地黄汤8.56g生药·kg-1·d-1）、西药组（强力霉素20mg·kg-1·d-1）、中西组（知柏地黄汤+强力霉素）,除假手术组外,其他组均采用经大鼠膀胱注射UU建立UU感染动物模型,连续灌胃21d后处死,取标本检测精液子质量,分光光度法检测精子线粒体Na+-K+-ATP酶、Ca2+-Mg2+-ATP酶活性。结果:与假手术组比较,UU感染模型大鼠精子浓度、精子活动率,a+b级精子百分率及精子线粒体Na+-K+-ATP酶、Ca2+-Mg2+-ATP酶活性下降（P

Objective: To research the effects of Zhibai Dihuang Decoction on activity of Na~+-K~+-ATP enzyme and Ca~(2+)-Mg~(2+)-ATP enzyme in spermaticmitochondria of ureaplasma urealyticum (UU) infected rat model. Methods: Eighty male SD rats were randomly divided into 5 groups: sham operation group, model group, Chinese medicine group (Zhibai Dihuang Decoction 8.56g crude drug·kg~(-1)·d~(-1)), western medicine group (doxycycline 20mg·kg~(-1)·d~(-1)), integration of traditional Chinese and western medicine group (Zhibai Dihuang Decoction + equivalen...