期刊论文

中文

中华中医药杂志

1673-1727

2017

32

3

1044-1049

国家自然科学基金项目(No.81373601) 湖南省自然科学基金项目(No.2012WK3008) 美国中西部生物医学研究基金项目(No.00929)~~

本校为第一机构

目的:探索四妙勇安汤对脑出血后脑内血红素和铁含量的降低作用及其机制。方法:在大鼠自体血脑出血动物模型上观察四妙勇安汤对大鼠神经缺陷症状、体温、脑内游离血红素浓度、铁含量在不同时间点的变化,同时检测脑毛细血管内血红素排出蛋白即乳腺癌抵抗蛋白(BCRP)和猫白血病病毒C组受体(FLVCR)、脑组织和血液中相关炎性细胞因子包括白细胞介素(IL)-1β、IL-6、肿瘤坏死因子-α(TNF-α)以及血中红素转运蛋白(HPX)的表达水平。结果:脑出血造模后动物行为学观察显示治疗组神经功能缺损评分在各时间点均低于对照组(P

Objective: To investigate whether Simiao Yong’an Decoction can remove the accumulated free hemin from the brain and decrease brain iron content in animal ICH models for the first time. Methods: Nine-week-old male Wister rats were stereotactically injected with 100μL of autologous whole blood into their global pallidus at the coordinates of 1.4mm anterior, 5.6mm ventral, and 3.2mm lateral to the bregma. Animals were randomly divided into treatment group and control group after surgery. Rats in treatment group were fed with Simiao Yong’an Deco...