期刊论文

中文

中华中医药杂志

1673-1727

2017

32

1

238-241

国家自然科学基金项目（No.81173326）,国家自然科学基金青年基金项目（No.81303049） 高等学校博士学科点专项科研基金资助项目（No.20124323110001） 湖南省中医药科研计划课题项目（No.2013117,No.2015134）~~

本校为第一机构

目的:观察隔药饼灸对功能性消化不良(FD)肝郁脾虚模型大鼠HPA轴中枢相关受体及激素的影响,探讨隔药饼灸治疗FD可能的作用机制。方法:将SD大鼠随机分为空白(A)组、模型(B)组、隔药饼灸(C)组、艾炷灸(D)组和逍遥散(E)组,每组10只,除A组外,其余4组采用复合病因造模法造模,连续3周;再按被试因素施加方法,分别进行隔药饼灸、艾炷灸和逍遥散灌胃治疗14d;实验结束后采用RT-PCR检测下丘脑、垂体糖皮质激素受体(GR)mRNA表达,ELISA检测下丘脑促肾上腺皮质激素释放激素(CRH)、垂体促肾上腺皮质激素(ACTH)及肾上腺皮质酮(CORT)的含量。结果:与A组比较,B组大鼠GR mRNA在下丘脑及垂体的表达显著下降(P

Objective: To explore the effects of herbal cake-separated moxibustion on related receptors and hormones of HPA axis in rat model of functional dyspepsia (FD) with liver stagnation and spleen deficiency syndrome. Methods: SD rats were randomly divided into five groups: the control group (A), the model group (B), the herbal cake-separated moxibustion group (C), the moxa-cone moxibustion group (D) and the Xiaoyaosan group (E), 10 rats in each group. Except for group A, the rat model of FD with liver stagnation and spleen deficiency syndrome was established by multiple etiological factors includi...