期刊论文

中文

中华中医药杂志

1673-1727

2018

33

3

874-877

国家自然科学基金项目（No.30772824,No.81574031） 湖南省科技厅科研基金资助项目（No.2015SF2016-6） 湖南省发展改革委科研基金项目（No.湘发改投资[2014]658号） 湖南省***卫生人才“225”工程培养项目 长沙市科技计划重大专项（No.K1501014-31） 国家中医药管理局中医眼科学重点学科建设项目 湖南省中医五官科学重点学科建设项目

本校为第一机构

目的:观察密蒙花颗粒剂对去势雄兔泪腺细胞肿瘤坏死因子α(TNF-α)、白细胞介素-1β(IL- 1β)表达的影响,探究其治疗干眼症的机制。方法:将30只雄兔随机分为空白组、模型组、密蒙花颗粒剂组、安慰剂组和睾酮组。空白组除外均行双侧睾丸及附睾切除术建立干眼症模型。密蒙花颗粒剂组予密蒙花颗粒剂灌胃;安慰剂组予0.9%氯化钠溶液灌胃;睾酮组注射丙酸睾酮注射液。给药4周后免疫组化法检测泪腺细胞炎性因子TNF-α、IL-1β表达。结果:与空白组比较,模型组和安慰剂组TNF-α、IL-1β的表达显著升高(P

Objective: To observe the effects of Buddleia Granules on the expression of TNF-α and IL-1β in lacrimal gland cells of castrated male rabbit. To explore the mechanism of treatment of dry eye. Methods: Thirty male rabbits were randomly divided into blank group, model group, Buddleia Granules group, placebo group and testosterone group. Except for the blank group, bilateral testicular and epididymal resection were performed to establish the dry eye model. The rabbits in the Buddleia Granules group were treated by the granules of Buddleia. The r...