期刊论文

Randomized controlled trial of modified Guipi Decoction in the treatment of post-stroke depression combined with anxiety

中文

中华中医药杂志

1673-1727

2018

33

12

5522-5525

王净净全国名老中医药专家传承工作室(No.国中医药人教发[2016]42号) 湖南省研究生科研创新项目(No.CX2016B354) 中医诊断学国家重点学科开放基金(No.2015ZYZD27).

本校为其他机构

目的:观察归脾汤加味治疗脑卒中后抑郁伴焦虑共病(PSCAD)的临床疗效及安全性评估。方法:将80例PSCAD患者随机分为中药组(40例)和对照组(40例)。对照组口服艾司西酞普兰片,中药组用归脾汤加味加减。两组均观察6周。治疗前后进行汉密尔顿抑郁量表(HAMD)评分、汉密尔顿焦虑量表(HAMA)评分进行评分,测定血清5-HT、NE、BDNF水平,观察临床疗效,以不良反应量表(TESS)评估安全性。结果:治疗2周后,中药组HAMD评分低于对照组(P

Objective: To observe the clinical therapeutic effects of modified Guipi Decoction in the treatment of poststroke depression combined with anxiety. Methods: Eighty cases with PSD were randomly divided into the Chinese traditional medicine (TCM)group (40 cases) and control group (40 cases). The control group was treated with Escitalopram, the TCM group was treated with modified Guipi Decoction. All of patients in two group were evaluated by Hamilton Depression Scale (HAMD) and Hamilton Anxiety Scale(HAMA)before and after treatment. Serum levels of 5-HT, NE and BDNF were determined for observing...