期刊论文

Effects of Huluan Decoction on the proteins expression of TGF-β/Smads signal pathway in super ovulation mice with chronic stress

中文

中华中医药杂志

1673-1727

2018

33

8

3332-3335

No.81303003:国家自然科学基金 No.81403427:国家自然科学基金

本校为第一机构

目的:观察护卵汤对慢性应激超排卵小鼠卵巢转化生长因子β(TGF-β)/Smads信号通路相关蛋白表达的影响。方法:建立慢性应激小鼠模型,将模型小鼠随机分为中药(护卵汤)组、西药(生长激素+阿司匹林)组和模型组,并设正常组。模型组和正常组给予0.9%氯化钠溶液,治疗组给予相应的药物。在超排卵后第3天处死小鼠10只;注射绒毛膜促性腺激素(HCG)24h后处死余下小鼠取卵巢。Western Blot检测卵巢TGF-β1、 P-Smad3及卵泡刺激素受体(FSHR)蛋白表达。结果:模型组卵巢TGF-β1、P-Smad3及FSHR蛋白表达较正常组同期均显著降低(P

Objective： To observe the effects of Huluan Decoction on the proteins expression of TGF- β/Smads signal pathway in super ovulation mice with chronic stress. Methods： The mice were randomly divided into model group, Chinese medicine group （Huluan Decoction）, western medicine group （growth hormone plus aspirin） and normal group （no movement limit）. The mice of model group and normal group were given normal saline （NS）, while treatment groups were given the corresponding drugs. A group of mice were killed on the third day after superovu...