期刊论文

Protective effect and mechanism of Shuangdan Mingmu Capsule on rabbit retina of diabetic retinopathy

中文

中华中医药杂志

1673-1727

2019

34

4

1423-1426

No.81473737:国家自然科学基金 No.81874493:国家自然科学基金

本校为第一机构

目的:探讨双丹明目胶囊对糖尿病视网膜病变(DR)兔视网膜的保护作用,并阐明其可能的保护机制。方法:采用重复性静脉注射四氧嘧啶(200mg/kg)建立DR兔模型,并随机分为模型组,双丹明目胶囊高、中、低剂量组(2.88、1.44、0.72g/kg),阳性药组(羟苯磺酸钙,5.8mg/kg),以正常兔为正常组。连续给药30d后,取兔血浆做血液分析,HE染色观察视网膜损伤情况,ELISA试剂盒检测视网膜中超氧化物歧化酶(SOD)、丙二醛(MDA)、血栓素B_2(TXB_2)、6-酮-前列腺素F_(1α)(6-Keto-PGF_(1α))含量。结果:高剂量组和阳性药组DR模型兔的视网膜损伤情况均显著减轻。高剂量组血糖值显著降低(P

Objective: To explore the protective effect of Shuangdan Mingmu Capsule on the rabbit retina of diabetic retinopathy (DR) and to clarify its possible protective mechanism. Methods: DR rabbit models were established by repetitive intravenous injection of alloxan (200mg/kg) and randomly divided into model group, high, medium and low dose of Shuangdan Mingmu Capsule groups (2.88, 1.44, 0.72g/kg), positive drug group (Calcium Dobesilate, 5.8mg/kg), while normal rabbits as control group. After thirty days of the continuous administration, the blood ...