期刊论文

Effects of the compatibility of Astragali Radix and Angelicae Sinensis Radix on the inflammatory response of rats with intima hyperplasia

中文

中华中医药杂志

1673-1727

2019

34

2

580-584

国家自然科学基金面上项目（No.81473581）~~；

本校为第一机构

目的:研究黄芪-当归配伍对大鼠血管内膜增生炎性反应的影响。方法:将SD大鼠分为芪归1∶1组、芪归5∶1组、单用黄芪组、单用当归组、阿托伐他汀组、模型组和假手术组,采用球囊导管损伤大鼠血管内皮造成胸腹主动脉血管内膜增生模型,同时灌胃药物,连续给药14d后行腹主动脉穿刺采血分离血浆,ELISA法检测血浆炎性反应因子白细胞介素-1β(IL -1β)、肿瘤坏死因子-α(TN F -α)、单核细胞趋化因子-1 (MCP-1)含量;取胸腹主动脉,免疫组化法检测血管局部细胞间黏附分子-1(ICAM-1)、血管细胞黏附分子-1 (VCAM-1)的表达。结果:内膜损伤14d后,血管局部和血浆中炎性反应因子含量均显著增加。与模型组比较,单用...

Objective: To study the effect of the compatibility of Astragali Radix and Angelicae Sinensis Radix on the inflammatory response of rats with intima hyperplasia. Method: SD rats were divided into Astragali Radix Angelicae Sinensis Radix 1 : 1 group, Astragali Radix Angelicae Sinensis Radix 5 : 1 group, Astragali Radix alone group, Angelicae Sinensis Radix alone group, atorvastatin control group, model group and sham operation group. A model of intimal hyperplasia of thoracoabdominal aorta was established by balloon catheter injury in rats' vasc...