期刊论文

Comparative study on the transdermal properties of eczema nano cream and eczema cream in vitro

中文

中华中医药杂志

1673-1727

2019

34

4

1765-1769

“十一五”国家科技支撑计划项目（No.2008BAI53B042）~~；

本校为第一机构

目的:探索湿疹纳米乳膏体外透皮特性并与湿疹乳膏比较,从而评价湿疹纳米乳膏的皮肤靶向特征。方法:以两种制剂中丹皮酚、盐酸小檗碱、苦参碱及氧化苦参碱累积透皮百分率为测定指标,用改良的Franz扩散池及离体兔皮进行实验,高效液相法测定不同时间透皮接收液中及皮肤内各成分的含量。比较两种制剂透皮速度、透皮量及各成分皮肤内储量的差异。结果:湿疹纳米乳膏与湿疹乳膏透皮动力学模型相同,湿疹纳米乳膏较湿疹乳膏透皮速率慢1.4倍以上;湿疹纳米乳膏透皮量仅为湿疹乳膏的70%左右;湿疹纳米乳膏皮肤潴留量是湿疹乳膏的2.5倍以上,湿疹纳米乳膏皮内潴留量占透皮总量的百分比是湿疹乳膏的2.0倍以上。结...

Objective: To explore the skin transdermal characteristics of eczema nano cream in vitro and compare it with eczema cream, so as to evaluate targeted characteristics of skin of eczema nano cream. Methods: The transdermal absorption percentage of paeonol, matrine, oxymatrine, berberine hydrochloride in the two preparations were used as measure index, and the experiment were finished by improved Franz diffuser cell and rabbit skin in vitro. The contents of different components in the transdermal receiving solution and the skin at different time w...