期刊论文

Effects of electro-acupuncture on the expression of receptors of Glu and GABA in the cerebral cortex of rats with SCA

中文

中华中医药杂志

1673-1727

2019

34

1

325-327

国家自然科学基金项目（No.81673886）~~；

本校为第一机构

目的:观察和分析电针对脑卒中痉挛状态(SCA)大鼠大脑皮质中神经兴奋因子谷氨酸(Glu)与神经抑制因子γ-氨基丁酸(GABA)二者含量与表达的影响,从而论证针刺对SCA的缓解作用。方法:将32只SD大鼠随机分为空白组、假手术组、模型组、电针组(模型+电针法针刺阳陵泉、曲池),每组各8只。运用线栓法制作脑卒中痉挛状态模型,造模成功后第1天开始治疗,连续3d。以肌张力评分评价模型和针刺疗效,运用ELISA法分析大鼠大脑皮质中Glu、GABA的含量,RT-PCR法观察大鼠大脑皮质mGluR1a mRNA、GABABR1 mRNA的表达。结果:治疗前,模型组、电针组与空白组、假手术组比较,肌张力评分评分明显升高(P

Objective: To observe and analyze the effects of electro-acupuncture on the content and expression of neuronal excitatory factor Glu and neuro-inhibitory factor GABA in cerebral cortex of rats with SCA, so as to demonstrate the relieving effect of acupuncture on SCA. Methods: Thirty-two SD rats were randomly divided into control group, sham operation group, model group and electro-acupuncture group with model add electro-acupuncture at Yanglingquan (G34) and Quchi (LI11). There were eight rats in each group. The model of SCA was established by wire bolting method. Treatment started on the firs...