期刊论文

Establishment of functional dyspepsia model of liver depression and spleen deficiency

中文

中华中医药杂志

1673-1727

2019

34

7

2944-2948

国家自然科学基金面上项目(No.81373577) 国家自然科学基金青年科学基金项目(No.81403384) 湖南省自然科学基金项目(No.2017JJ3248) 湖南省教育厅优秀青年项目(No.15B181) 湖南中医药大学校级创新性实验课题.

本校为第一机构

目的:探讨建立功能性消化不良(FD)肝郁脾虚证的动物模型方法。方法:健康SD大鼠30只随机分为5组:高脂组:高脂+束缚+游泳、番泻叶组:番泻叶煎剂+束缚+游泳、复合组:高脂+番泻叶煎剂+束缚+游泳、夹尾对照组:夹尾刺激+束缚+游泳、空白对照组。观察大鼠的饮食、大便、毛发、精神状态,检测胃排空率、小肠推进率及组织病理观察。结果:该造模方法制造的模型,符合FD动物模型的生物学特征。与空白对照组比较,复合组大鼠进食量显著减少(P

Objective:To establish an animal model for functional dyspepsia (FD) with liver depression and spleen deficiency.Methods:A total of 30 healthy SD rats were randomly divided into 5 groups:high fat group:high fat+tethered+swimming group,Fanxieye group:Fanxieye Fried Agent+tethered+swimming group,compound group:high fat+Fanxiye Fried Agent+tethered+swimming,clamp control group:clip tail stimulation+restraint+swimming,blank control group.The dietary,stool,hair and mental state of the rats were observed.The gastric motility,the small intestine propulsion rate and the tissue pathology excitability w...