期刊论文

Study on the effect of auxiliary anti-lung cancer and immune regulation of pachymaran

中文

中华中医药杂志

1673-1727

2020

35

10

4937-4940

国家自然科学基金项目(No.81703919) 中国博士后基金项目(No.2017M622587) 湖南补天药业合作研发基金项目 湖南省高校科技创新团队“感染性疾病中医药防治研究”资助项目(No.15) 湖南中医药大学基础医学学科 长沙市杰出创新青年培养计划项目(No.kq1905037)。

本校为第一机构

目的:研究茯苓多糖辅助增强长春瑞滨和顺铂对肺癌的治疗效果及对免疫因子的调节作用。方法:A549细胞皮下接种于BALB/c小鼠,建立肿瘤模型,随机分为4组:生理盐水组、茯苓多糖组、长春瑞滨+顺铂组、茯苓多糖联合长春瑞滨+顺铂组。给药后测定各组小鼠生长状态、体质量变化、移植瘤大小及抑瘤率、脾脏指数等,ELISA法检测白介素-2(IL-2)、肿瘤坏死因子-α(TNF-α )的表达。结果:与长春瑞滨+顺铂组比较,茯苓多糖联合长春瑞滨+顺铂组体质量减轻百分率、平均肿瘤体积显著减小(P

Objective: To study the effect on anti-lung cancer and immune regulation of Vinorelbine and CisPlatin improved by pachymaran. Methods: The lung cancer model was established by hypodermic injection with the A549 cells in BALB/c mice. These mice were randomly divided into 4 groups: normal saline group, pachymaran group, Vinorelbine and CisPlatin group, pachymaran combined with Vinorelbine and CisPlatin group. The general state, body mass changes, tumor size, tumor inhibition rate and spleen index in each group were compared, and the levels of IL-...