This paper aimed to summarize TCM master LIU Zu-yi's experience in the treatment of peri-menopausal insomnia with invigorating the kidney, dispersing stagnated liver qi, and tranquillization method. In his opinion, the main pathogenesis of peri-menopausal insomnia is the kidney deficiency, liver depression and heart restlessness. Therefore, the foremost treatment should be based on invigorating the kidney, dispersing stagnated liver qi and calming heart for tranquillization, as well as strengthening spleen a...