期刊论文

Discussion of late-onset hypogonadism in male's understanding of traditional Chinese medicine and western medicine and the possible mechanism of traditional Chinese medicine intervention

中文

中华中医药杂志

1673-1727

2020

35

3

1327-1331

国家自然科学基金(No.81202706,No.81673984) 湖南省自然科学基金(No.2018JJ3402) 长沙市科技计划项目经费资助-长沙市杰出创新青年培养计划(No.kq1802015) 湖南省***卫生人才225工程医学学科骨干人才培养对象(No.湘卫函[2019]196号) 湖南创新型省份建设专项经费资助-“湖湘青年英才”支持计划(No.2019RS2041) 中华中医药学会“青年人才托举工程”。

本校为第一机构

男性迟发性性腺功能减退症(LOH)是中老年男性常见病、多发病,中、西医对其病因病机、诊治等认识存在差异与统一,以睾酮水平低下为研究关键切入点,睾酮补充治疗(TST)是LOH治疗的重要方法之一,但其剂量、疗程、安全性等问题尚未解决。中医药基于辨证论治理论体系,可以整体改善LOH患者症状,具有一定优势。文章同时从Leydig细胞睾酮合成酶、活性氧簇(ROS)、自噬、旁分泌、雄激素受体(AR)、下丘脑-垂体-睾丸轴等多靶点、多途径对中医药干预LOH的可能机制提供研究思路。

Late-onset hypogonadism in male (LOH) is a common and frequently-occurring disease in middle-aged and elderly men, traditional Chinese medicine (TCM) and western medicine have different and unified understandings about the etiology, pathogenesis, diagnosis, and treatment of LOH. Taking the decrease of testosterone level as the key entry point, testosterone supplementation therapy (TST) is one of the important methods for LOH treatment, but its dosage, course safety and other issues have not yet been resolved. The TCM based on syndrome differentiation theory can improve the symptoms of LOH pati...