期刊论文

Protective effect of HNA-1 on dexamethasone-induced thymus atrophy mice and its effect on RLR signal pathway

中文

中华中医药杂志

1673-1727

2020

35

9

4649-4653

国家自然科学基金项目(No.81573822) 湖南省研究生科研创新项目(No.CX2017B445)。

本校为第一机构

目的:探讨中药复方湘艾一号方（HNA-1）对地塞米松诱导的胸腺萎缩、胸腺输出功能的保护作用及胸腺RLR信号通路表达的影响。方法:将C57BL/6小鼠,随机分为正常对照组、模型组、HNA-1低、中、高剂量治疗组,左旋咪唑组。观察各组小鼠胸腺形态改变,检测外周血中T细胞受体重排删除环（TRECs）的含量、CD4+ T初始亚群细胞的比例,并检测胸腺组织RLR/MAVS/IFN-α/β通路的表达情况。结果:模型组小鼠胸腺严重萎缩,组织结构破坏明显,外周血TRECs下降;RIG-Ⅰ、MDA5、LGP2和IFN-α/β表达上调明显。与模型组比较,HNA-1治疗组小鼠胸腺指数改变不显著,但胸腺细胞数量增加,以中、低剂量组较为明显;外周血TRECs含...

Objective: To investigate the effects of HNA-1, a traditional Chinese medicine regimen, on thymus output and RLR signaling pathway in thymic atrophy induced by dexamethasone in mice. Methods: C57BL/6 mice were randomly divided into 6 groups, including normal control, model (intraperitoneal DEX injection) group, HNA-1 treated groups (administrated with HNA-1 in low, middle, and high doses), and Levamisole group. The changes of thymus morphology were measured, the routine pathology examinations were implemented, as well as the expressions of RLR/...