期刊论文

Study on differentially expressed genes and Chinese medicine prediction of Crohn's disease based on bioinformatics analysis

中文

中华中医药杂志

1673-1727

2020

35

5

2562-2567

国家自然科学基金项目（No.8197151189）~~；

本校为其他机构

目的:本研究通过生物信息学技术分析克罗恩病(CD)患者与正常人的基因芯片数据,筛选CD的差异表达基因,从而探讨CD的发病机制,进而预测治疗CD的潜在中药。方法:从基因表达数据库(GEO)下载GSE4183基因芯片,使用R语言分析得到上调和下调的差异表达基因,通过String数据库、Cytoscape软件及其插件分析得到差异表达基因的核心基因,并对差异基因进行基因本体及京都基因与基因组百科全书分析,将核心基因与医学本体信息检索平台相互映射,筛选治疗CD的中药。结果:筛选出931个差异表达基因,其中包括369个下调基因和562个上调基因。上调的15个核心基因包括STAT3、STAT1、CD44、CXCL10、IRF1、 ISG15、MMP9、V...

Objective: In this study, bioinformatics technology was used to analyze the gene chip data of patients with Crohn's disease (CD) and healthy people, to screen for differentially expressed genes of CD, to explore the pathogenesis of CD, and then to predict the treatment of potential Chinese medicine for disease. Methods: The GSE4183 gene expression profile was downloaded from the gene expression database (GEO), and the differentially expressed genes were analyzed by R software, the differentially expressed genes contain up-regulated and down-reg...