期刊论文

Effects of electroacupuncture on gastric mucosal Ghrelin and Survivin dynamic expression in rats with acute gastric mucosal lesion

中文

中华中医药杂志

1673-1727

2020

35

01

141-145

深圳市创新科技计划项目（No.JCYJ20160406140612883）； 国家自然科学基金项目（No.81473751）~~；

本校为其他机构

目的:观察电针治疗急性胃黏膜损伤大鼠过程中不同节点的饥饿素(Ghrelin)和生存素(Survivin)差异表达,探讨电针治疗急性胃黏膜损伤的时效关系。方法:将72只SD大鼠根据干预时间随机分为1、4、7d 3批,各批又分成4个亚组:正常组、模型组、胃经穴位组和胆经穴位组,每组6只。采用75%乙醇灌胃法复制急性胃黏膜损伤大鼠模型,并分别对胃(胆)经穴位组的大鼠进行电针干预1、4、7d (30min/d)。干预结束后于光镜下观察胃黏膜形态,Western Blot测定胃黏膜脑肠肽Survivin及Ghrelin的动态表达,并分析和比较其随干预治疗的进程出现的变化结果:干预1d,模型组大鼠胃黏膜溃疡灶明显,Ghrelin降低(P

Objective: To observe the dynamic relative expression of brain-gut peptides in gastric mucosa of rats with the acute gastric mucosal lesion (AGML) by electroacupuncture at the stomach meridian, and to explore the time effect relationship of electroacupuncture in the treatment of AGML. Methods: Seventy-two male SD rats were randomly divided into three groups: Id group, 4d group, and 7d group. Each group was divided into 4 subgroups: normal group, model group, stomach meridian acupoint group (S group) and gall bladder meridian acupoint group (GB group), with 6 rats in each group. AGML model was ...