期刊论文

Effects of cerebral ischemia-reperfusion injury on the pathological morphology of neuron injury in cortex EPL and hippocampus CA1 regions in rats

中文

中华中医药杂志

1673-1727

2020

35

3

1488-1492

国家自然科学基金面上项目(No.81774129) 湖南省自然科学基金青年项目(No.2018JJ3382,No.2019JJ50441) 湖南省教育厅优秀青年项目(No.18B246) 湖南省中医药管理局科研项目(No.2018025) 2018年湖南中医药大学大学生研究性学习和创新性实验计划课题(No.2018017)。

本校为第一机构

目的:研究脑缺血再灌注损伤对大鼠大脑皮质外锥体层(EPL)区和CA1区神经元损伤病理形态的影响。方法:40只SD大鼠随机分为假手术组和MCAO组,MCAO组大鼠行大脑中动脉线栓法脑缺血/再灌注模型制备术造模,术后72h根据神经行为学评分标准记录大鼠行为活动,HE观察脑组织形态病理变化,尼氏染色观察皮质EPL区和海马CA1区神经元数量,高尔基染色观察神经元树突形态和树突棘密度。结果:与假手术组比较,MCAO组大鼠的神经行为评分升高(P

Objective: To investigate the effects of cerebral ischemia-reperfusion injury on the pathological morphology of neuron injury in cortex EPL and hippocampus CA1 regions in rats. Methods: A total of 40 SD rats were randomly divided into sham operation group and middle cerebral artery occlusion (MCAO) group. The local cerebral ischemia-reperfusion model was reproduced by MCAO. Neurofunctional score was used to record the behavioral activities of rats 72h after surgery. HE staining was used to observe the morphological and pathological changes of brain tissue. Nissl's staining was used to observe ...