期刊论文

中文

中华中医药杂志

1673-1727

2022

37

4

1938-1941

国家自然科学基金项目(No.81874430) 湖南省研究生创新项目(No.CX20200779,No.CX20200753,No.CX20200778)。

本校为第一机构

目的:观察隔药饼灸对动脉粥样硬化易损斑块兔腹主动脉组织中磷脂酰肌醇3-激酶(PI3K)、蛋白激酶B (AKT)、肿瘤坏死因子-α (TNF-α)表达的影响。方法:随机将新西兰大耳白兔分为空白组、模型组、直接灸组、隔药饼灸组和药物组,每组12只,采用球囊损伤腹主动脉加高脂饲料喂养结合建立兔AS易损斑块模型。造模成功后,分别对直接灸组、隔药饼灸组、药物组进行艾柱灸、艾柱+药饼、口服阿托伐他汀钙片干预。采用免疫组化法和实时荧光定量PCR法检测兔腹主动脉PI3K、AKT、TNF-α的灰度值和基因表达。结果:与空白组比较,模型组PI3K、AKT、TNF-α灰度值表达显著下降(P

Objective:To observe the effect of medicinal cake-separted moxibustion on the expression of phosphatidylinositol 3-kinase(PI3K),protein kinase B(AKT)and tumor necrosis factor-α(TNF-α)in abdominal aorta of rabbits with atherosclerotic vulnerable plaque.Methods:New Zealand white rabbits were randomly divided into 5 groups,including blank group,model group,direct moxibustion group,medicinal cake-separted moxibustion group and western medicine group.Rabbits with AS vulnerable plaque model were fed with high-fat diet combined with balloon injury o...