期刊论文

Effects of Guilu-Erxian-Glue on the structure and function of sperm mitochondria and the expression of SLC22A14 in asthenospermia rat model induced by Tripterygium wilfordii polyglycoside

中文

中华中医药杂志

1673-1727

2023

38

08

3576-3581

国家自然科学基金面上项目(No.81774324,No.81973863) 湖南中医药大学中西医结合一流学科开放基金项目(No.2020ZXYJH29,No.2021ZXYJH03) 深圳市宝安区医疗卫生基础研究项目(No.2020JD505)。

本校为第一机构

目的:研究龟鹿二仙胶对雷公藤多苷(GTW)诱导弱精子症(AZS)大鼠精子线粒体结构和功能及溶质载体家族22成员14(SLC22A114)表达的影响。方法:60只SD大鼠随机分为正常组,模型组,龟鹿二仙胶低、中、高剂量组、...展开更多 目的:研究龟鹿二仙胶对雷公藤多苷(GTW)诱导弱精子症(AZS)大鼠精子线粒体结构和功能及溶质载体家族22成员14(SLC22A114)表达的影响。方法:60只SD大鼠随机分为正常组,模型组,龟鹿二仙胶低、中、高剂量组、五子衍宗丸组,各10只;除正常组外,各组均给予GTW40mg·kg-1·d-1连续灌胃4周造模AZS大鼠模型;造模结束后正常组、模型组给予0.9%氯化钠溶液灌胃4周,龟鹿二仙胶低、中、高剂量组分...

Objective:To study the effects of Guilu-Erxian-Glue on the structure and function of sperm mitochondria and the expression of solute carrier family 22 member 14(SLC22A114)in asthenospermia(AZS)rat model induced by Tripterygium wilfordi polyglycosid(GTW).Methods:Sixty SD...MORE Objective:To study the effects of Guilu-Erxian-Glue on the structure and function of sperm mitochondria and the expression of solute carrier family 22 member 14(SLC22A114)in asthenospermia(AZS)rat model induced by Tripterygium wilfordi polyglycosid(GTW).Methods:Sixty SD r...