Gap junction channels as potential targets for the treatment of major depressive disorder

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成果类型：

期刊论文

作者：

Ren, Qian;Wang, Zhen-Zhen;Chu, Shi-Feng;Xia, Cong-Yuan;Chen, Nai-Hong*

通讯作者：

Chen, Nai-Hong

作者机构：

[Wang, Zhen-Zhen; Chen, Nai-Hong; Ren, Qian; Xia, Cong-Yuan; Chu, Shi-Feng] Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China.

[Wang, Zhen-Zhen; Chen, Nai-Hong; Ren, Qian; Xia, Cong-Yuan; Chu, Shi-Feng] Chinese Acad Med Sci, Neurosci Ctr, Beijing 100050, Peoples R China.

[Wang, Zhen-Zhen; Chen, Nai-Hong; Ren, Qian; Xia, Cong-Yuan; Chu, Shi-Feng] Peking Union Med Coll, Beijing 100050, Peoples R China.

[Chen, Nai-Hong] Hunan Univ Chinese Med, Coll Pharm, Changsha 410208, Hunan, Peoples R China.

通讯机构：

[Chen, Nai-Hong] C

[Chen, Nai-Hong] P

[Chen, Nai-Hong] H

Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China.

Chinese Acad Med Sci, Neurosci Ctr, Beijing 100050, Peoples R China.

语种：

英文

关键词：

*Antidepressants;*Connexin 43;*Connexin 43 blockers;*Gap junction channels;*Major depressive disorder

期刊：

Psychopharmacology

ISSN：

0033-3158

年：

2018

卷：

235

期：

页码：

1-12

DOI：

10.1007/s00213-017-4782-7

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81573636, U1402221, 81560663]; PUMC Youth Fund [3332016058]; Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities [2014RC03, 2016RC350002]; CAMS Innovation Fund for Medical Sciences (CIFMS) [2016-I2M-1-004]; Scientific Research Foundation of the Higher Education Institutions of Human Province [15K091]; Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study [BZ0150]

机构署名：

本校为通讯机构

院系归属：

药学院

摘要：

Major depressive disorder (MDD) remains a major public health problem worldwide. The association between MDD and the dysfunction of gap junction channels (GJCs) in glial cells, especially astrocytes, is still controversial. This review provides an overview of the role of astrocyte GJCs in LMDD. Exposure to chronic unpredictable stress caused a reduction in connexin expression in the rat prefrontal cortex, a result that is consistent with clinical findings reported in postmortem studies of brains from MDD patients. Chronic antidepressant treatment in these rats increased the expression of conne...

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Gap junction channels as potential targets for the treatment of major depressive disorder

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