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Polygonatum sibiricum polysaccharide alleviates inflammatory cytokines and promotes glucose uptake in high-glucose- And high-insulin-induced 3T3-L1 adipocytes by promoting Nrf2 expression

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成果类型:
期刊论文
作者:
Cai, Jialuo;Zhu, Yilin;Zuo, Yajie;Tong, Qiaozhen;Zhang, Zhiguo;...
通讯作者:
Li, XP;Yi, GQ
作者机构:
[Cai, Jialuo; Li, Xiaoping] Hunan Univ Chinese Med, Prevent Treatment Dis Ctr, Hosp 1, 95 Shaoshan Middle Rd, Changsha 410000, Hunan, Peoples R China.
[Zhu, Yilin] Hunan Univ Chinese Med, Student Affairs Off, Changsha, Hunan, Peoples R China.
[Zhang, Zhiguo; Zuo, Yajie] Hunan Univ Chinese Med, Dept Pharm, Hosp 1, Changsha 410000, Hunan, Peoples R China.
[Tong, Qiaozhen] Hunan Univ Chinese Med, Yueyang Affiliated Hosp, Yueyang 414000, Hunan, Peoples R China.
[Tong, Qiaozhen; Yi, Gangqiang] Hunan Univ Chinese Med, 300 Bachelors Rd, Changsha 410000, Hunan, Peoples R China.
通讯机构:
[Yi, GQ ; Li, XP ] H
Hunan Univ Chinese Med, Prevent Treatment Dis Ctr, Hosp 1, 95 Shaoshan Middle Rd, Changsha 410000, Hunan, Peoples R China.
Hunan Univ Chinese Med, 300 Bachelors Rd, Changsha 410000, Hunan, Peoples R China.
语种:
英文
关键词:
antiinflammatory agent;cytokine;glucose;glucose transporter 4;heme oxygenase 1;insulin;interleukin 1beta;interleukin 6;Polygonatum extract;Polygonatum sibiricum polysaccharide;polysaccharide;transcription factor Nrf2;tumor necrosis factor;unclassified drug;antiinflammatory agent;cytokine;Nfe2l2 protein, mouse;polysaccharide;transcription factor Nrf2;3T3-L1 cell line;adipocyte;antiinflammatory activity;Article;cell proliferation;controlled study;cytokine release;drug isolation;drug mechanism;gene silencing;glucose transport;human;human cell;insulin resistance;non insulin dependent diabetes mellitus;Polygonatum;protein expression;animal;chemistry;drug effect;genetics;hyperglycemia;hyperinsulinism;immunology;mouse;non insulin dependent diabetes mellitus;Polygonatum;upregulation;3T3-L1 Cells;Adipocytes;Animals;Anti-Inflammatory Agents;Cytokines;Diabetes Mellitus, Type 2;Humans;Hyperglycemia;Hyperinsulinism;Mice;NF-E2-Related Factor 2;Polygonatum;Polysaccharides;Up-Regulation
期刊:
MOLECULAR MEDICINE REPORTS
ISSN:
1791-2997
年:
2019
卷:
20
期:
4
页码:
3951-3958
基金类别:
The present study was supported by grants from the youth program of the natural Science Foundation of Hunan province, china (grant no. 2019JJ5041), the natural Science Foundation of Hunan university of chinese Medicine, china (grant no. ZYYdX201740) and the State administration of Traditional chinese Medicine of the People's republic of China Construction Project of Zhang Zhiguo Heritage Studio related to the old chinese Medicine experts [grant no. (2016)42]. The present study was supported by grants from the youth program of the Natural Science Foundation of Hunan province, China (grant no. 2019JJ5041), the Natural Science Foundation of Hunan University of Chinese Medicine, China (grant no. ZYYDX201740) and the State Administration of Traditional Chinese Medicine of the People's Republic of China Construction Project of Zhang Zhiguo Heritage Studio Related to the Old Chinese Medicine Experts [grant no. (2016)42].
机构署名:
本校为第一且通讯机构
院系归属:
第一中医临床学院
药学院
摘要:
Polygonatum sibiricum polysaccharide (PSP) has been shown to alleviate hyperglycemia and reduce oxidative stress to delay the progression of diabetic retinopathy and cataracts. However, its role and underlying mechanisms in regulating type 2 diabetes mellitus (T2DM) remain unclear. Nuclear factor erythroid 2-related factor 2 (Nrf2) activation plays a protective role in T2DM. The present study focused on the effect of PSP on inflammatory cytokine secretion and Nrf2 expression in the adipocytes of T2DM patients. In this study, high-glucose- and h...

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