期刊论文

Tian, X.

英文

Frontiers in Pharmacology

1663-9812

2022

12

791269

10.3389/fphar.2021.791269

Joint Funds of the National Natural Science Foundation of China (Grant No. U20A20408); National Natural Science Foundation of China (82074450); Youth Project of National Natural Science Foundation of China (82104861); Natural Science Foundation of Hunan Province of China (NO: S2021JJQNJJ2158 and 2021JJ40408); Outstanding Youth Project of Hunan Education Department (NO.20B452); Hunan Provincial High-level Health Talents “225” Project (Xiang Weihan (2019) No. 196); Hunan Clinical Research Center for Sexual and Reproductive Health of Traditional Chinese Medicine (2020SK4014); Open Fund Project of the State Key Laboratory Breeding Base of TCM Powder and Innovative Drugs Co-built by the Ministry and the Ministry (Scientific Correspondence (2020) No.8-04); Hunan First-class open discipline Fund of Integrated Chinese and Western medicine (2020ZXYJH19, 2019ZXYJH14).

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Background: Drug resistance is the major cause of increasing mortality in prostate cancer (PCa). Therefore, it an urgent to develop more effective therapeutic agents for PCa treatment. Xihuang pills (XHP) have been recorded as the efficient anti-tumor formula in ancient Chinese medical literature, which has been utilized in several types of cancers nowadays. However, the effect protective role of XHP on the PCa and its underlying mechanisms are still unclear. Methods: The active ingredients of XHP were obtained from the Traditional Chinese Medi...