Tanshinone IIA Ameliorates Inflammation Response in Osteoarthritis via Inhibition of miR-155/FOXO3 Axis

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Zhou, Biao;Li, Lin-Hui;Tan, Li-Ming;Luo, Wen-Bing;Xiong, Hui;...

通讯作者：

Zhu, Li-Guo

作者机构：

[Zhu, Li-Guo; Li, Lin-Hui; Zhou, Biao] Chinese Acad Chinese Med Sci, Wangjing Hosp, Dept Orthoped, Huajiadi St, Beijing 100102, Peoples R China.

[Zhou, Biao] Nanhua Univ, Xiangtan Hosp, Dept Orthoped, Xiangtan, Peoples R China.

[Tan, Li-Ming] Fourth Hosp Changsha, Dept Orthoped, Changsha, Peoples R China.

[Tan, Li-Ming] Changsha Hosp Trandit Chinese Med, Dept Orthoped, Changsha, Peoples R China.

[Luo, Wen-Bing] Chinese Med Hosp Linli Cty, Dept Orthoped, Linli, Peoples R China.

通讯机构：

[Zhu, Li-Guo] C

Chinese Acad Chinese Med Sci, Wangjing Hosp, Dept Orthoped, Huajiadi St, Beijing 100102, Peoples R China.

语种：

英文

关键词：

Tanshinone IIA;miR-155;FOXO3;Osteoarthritis;Inflammation

期刊：

Pharmacology

ISSN：

0031-7012

年：

2021

卷：

106

期：

1-2

页码：

20-28

DOI：

10.1159/000505493

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81574005, 81804120]; United Fund of Hunan Provincial Science and Technology Department and Municipal Health and Family Planning, China [B2017225]; Natural Science Foundation of Hunan ProvinceNatural Science Foundation of Hunan Province [2020JJ5555]; Scientific Research Project of Hunan Health and Family Planning Commission, China [B20180781]; Xiangtan City Medical Scientific Research Program, China [2018xtyx-12]

机构署名：

本校为其他机构

院系归属：

第一中医临床学院

第二中医临床医学院

摘要：

Background: Osteoarthritis (OA) is the most common joint disorder characterized by degeneration of the articular cartilage and joint destruction with an associated risk of mobility disability in elderly people. Although a lot of achievements have been made, OA is still regarded as an incurable disease. Therefore, the pathological mechanisms and novel therapeutic strategies of OA need more investigation. Methods: MTT assay was conducted to measure the viability of chondrocytes after LPS treatment. Cell apoptosis was analyzed by annexin V/propidi...

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Tanshinone IIA Ameliorates Inflammation Response in Osteoarthritis via Inhibition of miR-155/FOXO3 Axis

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