期刊论文

Establishment of Rat Model of Yin Deficiency and Edema Syndrome and Intervention Effect of Zhuling Decoction

中文

中医学报

1674-8999

2018

33

9

1686-1689,1727

10.16368/j.issn.1674-8999.2018.09.400

湖南省教育厅科学研究（优秀青年项目）资助项目（15B177）；

本校为第一机构

目的:评价并探讨一种类似阴虚水肿证大鼠模型制作方法并观察猪苓汤的干预作用.方法:100只雄性SPF级Wistar大鼠分为空白组(不做处理)、对照组(尾静脉注射生理盐水)、阿霉素组(尾静脉注射阿霉素),2周后24小时尿蛋白定量≥100 mg提示阿霉素肾病模型复制成功,弃去对照组、造模失败及死亡大鼠,重新分为空白组、阿霉素模型组、阴虚水肿组(阿霉素模型基础上连续灌服左甲状腺素钠片悬液)、猪苓汤组(阴虚水肿组基础上连续灌服猪苓汤).观察各组大鼠不同时间点皮肤含水量、肛温、甲状腺功能等变化,以猪苓汤干预反证该模型是否成立.结果:与空白组比较,阿霉素组大鼠第2周阴囊水肿明显,第4周皮肤含水量高于空白...

Objective ：To evaluate and explore a method in establishing a rat model of Yin deficiency and edema Syndrome and to observe the intervention effect of Zhuling Decoction. Methods ： 100 male SPF grade Wistar rats were randomly divided into blank group （no treatment）, control group （injecting saline into the tail vein） and adriamycin group （injecting adriamycin into the tail vein）. Two weeks later,the 24 h urine protein quantitation was more than or equal to 100 mg indicating that the adriamycin ne- phropathy model was successfully establi...