期刊论文

中文

中医学报

1674-8999

2020

35

2

329-333

10.16368/j.issn.1674-8999.2020.02.075

国家中医药管理局中医眼科学重点学科建设项目(ZK1801YK015) 湖南中医药大学中医学国内一流建设学科项目 湖南省研究生创新课题项目(CX2018B497) 中医药防治眼耳鼻咽喉疾病与视功能保护湖南省工程技术研究中心建设项目(2018TP2008) 长沙市科技计划项目(K1501014-31,kc1704005)。

本校为第一机构

目的:通过对蛴螬提取物干预实验性年龄相关性黄斑变性(age-related maculat degeneradon,AMD)实验研究,观察蛴螬提取物对实验眼脉络膜新生血管组织的趋化因子受体7(CXC chemokine receptor 7,CXCR7)及血管内皮生长因子(vascular endothelial growth factor,VEGF)表达的影响,同时比较口服、滴眼两种给药途径的差异。方法:建立病变易发生脉络膜新生血管(choroidal neovascularization,CNV)大鼠模型,将32只大鼠随机分成A、B、C、D 4组。A组:健康空白组(8只);B组:模型组(8只);C组:口服组(8只);D组:滴眼组(8只)。C组予以蛴螬提取物,按5.6 g·kg^-1,稀释至2 m L灌胃,每日1次;D组予以蛴螬滴眼液滴眼,每...

Objective:To observe the effects of Qicao(Grub)extract on the treatment of experimental age-related maculat degeneradon(AMD),and to observe the CXC chemokine receptor 7(CXCR7)and the expression of vascular endothelial growth factor(VEGF).At the same time,the differences between the oral and eye drops were compared.Methods:A rat model of choroidal neovascularization(CNV)prone to lesions was established,and 32 rats were randomly divided into four groups:A,B,C,and D:Group A:Healthy blank group(8 animals);Group B:model group(8 animals);group C:oral...