期刊论文

Effect of Yinchen Wuling Powder on RBP4 in Non-alcoholic Fatty Liver Disease Model Rats

中文

中医学报

1674-8999

2020

35

2

344-347

10.16368/j.issn.1674-8999.2020.02.078

湖南省教育厅重点项目(12A101) 湖南中医药大学大学生创新项目(1022/0001019010)。

本校为第一机构

目的:观察RBP4在非酒精性脂肪性肝病模型大鼠中的表达,并探讨茵陈五苓散对非酒精性脂肪肝病的治疗效果及作用机制。方法:60只SD大鼠随机分为空白对照组(15只)与实验组(45只)。空白对照组给予普通饲料,实验组大鼠饲喂改良以后的高脂饲料,制作非酒精性脂肪肝病模型,饲喂24周。造模成功后,将实验组的大鼠随机分为4组,非酒精性脂肪肝组、茵陈五苓散1.28 g·mL^-1组、茵陈五苓散0.64 g·mL^-1组和辛伐他汀对照组。每组大鼠进行灌胃,给予对应的药物治疗,6周后比较各组大鼠肝质量、体质量、肝指数、低密度脂蛋白胆固醇(low density lipoprotein cholesterin,LDL-C)、三酰甘油(triacylglycerol,TG)、总胆...

Objective:To observe the expression of RBP4 in non-alcoholic fatty liver disease model rats,and to explore the therapeutic effect and mechanism of Yinchen Wuling Powder on non-alcoholic fatty liver disease.Methods:Sixty SD rats were randomly divided into blank control group(15)and experimental group(45).The blank control group was given ordinary feed,and the experimental group rats were fed with modified high-fat feed to make a model of non-alcoholic fatty liver disease and fed for 24 weeks.After successful modeling,the rats in the experimental...