期刊论文

Mechanism of Jitongxiao Capsule in Treating Lumbar Disc Herniation Based on JNK/MAPK Signaling Pathway

中文

中医学报

1674-8999

2024

39

4

828-836

10.16368/j.issn.1674-8999.2024.04.141

LH2021H092:黑龙江省自然科学基金项目 :黑龙江省中医药经典普 ZYW2023-046:化研究专项课题项目 HLJSYL22011:黑龙江中医药大学双一流学科优秀青年基金项目

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目的:利用网络药理学方法和实验验证分析脊痛消胶囊治疗腰椎间盘突出症(lumbar disc herniation,LDH)的作用机制.方法:从中药系统药理学(Traditional Chinese Medicine Systems Pharmacology,TCMSP)、中药分子机理的生物信息学分析工具(Bioinformatics Analysis Tool for Molecular Mechanism of Traditional Chinese Medicine,BATMAN-TCM)、中医药资料@Taiwan和Swiss数据库中检索并筛选脊痛消胶囊的有效成分及其作用靶点,并使用GeneCards、人类孟德尔遗传(Online Mendelian Inher-itance in Man,OMIM)和DisGeNET数据库预测LDH的疾病靶点,再将活性成分作用靶点与疾病靶点进行映射,得到脊痛消胶囊...

Objective:Analyze the mechanism of Jitongxiao Capsule in treatment of lumbar disc herniation(LDH)using network phar-macology and experimental verification.Methods:Retrieve and screen the effective ingredients and targets of Jitongxiao Capsule from Traditional Chinese Medicine Systems Pharmacology(TCMSP),Bioinformatics Analysis Tool for Molecular Mechanism of Traditional Chinese Medicine(BATMAN-TCM),Traditional Chinese Medicine Information@Taiwan and Swiss databases.Use Genecards,on-line Mendelian inheritance in man(OMIM)and DisGeNET databases to predict the disease targets of LDH,and then map ...