期刊论文

Effects of Electroacupuncture at Neiguan Point on Creatine Kinase and Adenosine after Myocardial Ischemia and Reperfusion Injury

中文

同济大学学报(医学版)

1008-0392

2004

25

4

290-292

10.3969/j.issn.1008-0392.2004.04.005

湖南省自然科学基金资助项目 （OOJJY10 0 6）；

本校为其他机构

目的观察电针内关对心肌缺血再灌注损伤心肌肌酸激酶(creatinekrase,CK)和内源性保护物质腺苷的影响,探讨电针内关对心肌缺血再灌注损伤的保护作用及机制.方法wistar雄性大鼠50只,随机分为假手术组、缺血再灌注模型组、电针内关组、电针列缺组和电针合谷组,结扎大鼠冠脉左前降支造成心肌缺血模型,检测心肌CK和腺苷(adenosine,Ado)含量.结果内关穴组心肌CK含量低于模型组(P＜0.05),内关组血清中Ado含量高于模型组(P＜0.01).结论电针内关穴减少心肌缺血再灌注损伤CK的释放,从而减轻心肌缺血再灌注损伤;促进内源性保护物质Ado的释放,从而在一定程度上对心肌缺血再灌注损伤心肌起到保护作用.

Objective To investigate the protective mechanism of electroacupuncture at Neiguan point on myocardial cells of myocardial ischemia and reperfusion injury models of rats to see its relations to creatine kinase(CK) and Adenosine(Ado) which are endogenetic protective material after myocardial ischemia and reperfusion injury.Methods 50 wister rats were randomly divided into 5 groups:control group,MIR group,EA at Neigran group,EA at Hegu group,EA at Lieque group.The ischemia model was made by ligaturing the left anterior descending branch of coronary artery,The changes of CK and Ado were measured....